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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN12
All Species:
10
Human Site:
S744
Identified Species:
22
UniProt:
Q05209
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q05209
NP_001124480.1
780
88120
S744
I
E
C
P
P
T
F
S
D
K
R
E
Q
I
S
Chimpanzee
Pan troglodytes
XP_519168
792
88529
S756
I
E
C
P
P
T
F
S
D
K
R
E
Q
I
S
Rhesus Macaque
Macaca mulatta
XP_001082837
733
82786
L702
I
R
S
E
W
S
E
L
Q
S
Q
E
R
S
E
Dog
Lupus familis
XP_540396
757
85032
S721
T
E
C
R
A
I
F
S
N
Q
K
D
Q
I
S
Cat
Felis silvestris
Mouse
Mus musculus
P35831
775
86973
Q744
A
F
S
D
K
K
D
Q
I
T
K
S
P
A
E
Rat
Rattus norvegicus
NP_476456
766
85965
E735
T
F
S
D
K
K
E
E
I
T
E
S
L
T
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507461
747
83881
D715
A
G
E
Q
M
E
T
D
T
V
C
P
L
P
I
Chicken
Gallus gallus
XP_415970
1211
131521
I1165
S
N
K
T
P
T
D
I
L
P
Q
I
S
F
S
Frog
Xenopus laevis
NP_001084841
660
74123
H629
L
P
M
S
I
A
R
H
D
S
P
S
P
K
H
Zebra Danio
Brachydanio rerio
NP_956963
570
64484
T539
N
D
A
E
Q
K
S
T
E
T
P
V
S
G
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
S795
Y
D
L
V
G
I
P
S
H
D
G
T
F
D
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.5
91.4
88
N.A.
82.8
83.5
N.A.
74.6
48.3
58.2
46.7
N.A.
N.A.
N.A.
N.A.
28.9
Protein Similarity:
100
95.4
92.3
91
N.A.
88.3
88.8
N.A.
81.1
53.5
66.9
57.4
N.A.
N.A.
N.A.
N.A.
44
P-Site Identity:
100
100
13.3
46.6
N.A.
0
0
N.A.
0
20
6.6
0
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
33.3
73.3
N.A.
6.6
0
N.A.
0
26.6
13.3
26.6
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
19
0
10
0
10
10
0
0
0
0
0
0
0
10
0
% A
% Cys:
0
0
28
0
0
0
0
0
0
0
10
0
0
0
0
% C
% Asp:
0
19
0
19
0
0
19
10
28
10
0
10
0
10
0
% D
% Glu:
0
28
10
19
0
10
19
10
10
0
10
28
0
0
28
% E
% Phe:
0
19
0
0
0
0
28
0
0
0
0
0
10
10
0
% F
% Gly:
0
10
0
0
10
0
0
0
0
0
10
0
0
10
0
% G
% His:
0
0
0
0
0
0
0
10
10
0
0
0
0
0
10
% H
% Ile:
28
0
0
0
10
19
0
10
19
0
0
10
0
28
10
% I
% Lys:
0
0
10
0
19
28
0
0
0
19
19
0
0
10
0
% K
% Leu:
10
0
10
0
0
0
0
10
10
0
0
0
19
0
0
% L
% Met:
0
0
10
0
10
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
10
0
0
0
0
0
0
10
0
0
0
0
0
0
% N
% Pro:
0
10
0
19
28
0
10
0
0
10
19
10
19
10
0
% P
% Gln:
0
0
0
10
10
0
0
10
10
10
19
0
28
0
0
% Q
% Arg:
0
10
0
10
0
0
10
0
0
0
19
0
10
0
0
% R
% Ser:
10
0
28
10
0
10
10
37
0
19
0
28
19
10
46
% S
% Thr:
19
0
0
10
0
28
10
10
10
28
0
10
0
10
10
% T
% Val:
0
0
0
10
0
0
0
0
0
10
0
10
0
0
0
% V
% Trp:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _